Dietary supplement system for multifunctional anti-aging management and method of use

ABSTRACT

A dietary supplement system includes a dietary supplement composition for oral administration by an individual in the morning, the composition, including (a) a telomere maintenance complex including: Purslane extract (aerial parts); Turmeric rhizome extract (95% curcuminoids); Quercetin dehydrate, Cayenne pepper fruit; Vanadium (as vanadyl sulfate); Fenugreek seed;  Astragalus  root extract, Omega fatty acid complex including linoleic acid; alpha-linolenic acid; oleic acid borage seed oil gamma-linolenic acid), evening primrose oil fish body oil (eicosapentaenoic acid; docosahexaenoic acid); (b) a calorie restriction mimetics and gene expression complex including Trans-resveratrol (from  Polygonum cuspidatum  root extract); Pterostilbene Fisetin 50% ( Buxus microphlla  Sieb (stem and leaf; Alpha lipoic acid, Coenzyme Q-10, Betaine HCl, Sulfur (from methylsulfonylmethane); L-Carnitine tartrate; L-Carnitine HCl, and (c) a free radical scavenger complex, including Green tea leaf extract catechin and polyphenols); Anthocyanins (from bilberry fruit and grape skin extracts).

CROSS-REFERENCE TO RELATED APPLICATION

This application is a continuation of U.S. patent application Ser. No.13/573,386 filed Sep. 13, 2012 and titled “Dietary Supplement System forMultifunctional Anti-Aging Management and Method of Use,” which claimspriority to U.S. Provisional Patent Application No. 61/534,673 filedSep. 14, 2011. The content of each of these applications is herebyincorporated by reference herein in its entirety for all purposes.

BACKGROUND

The aging process is believed to relate to the failure of cellcomponents such as the cell nucleus to continue to replicate otherwisehealthy cells. This is believed to occur as a result of damage whichoccurs to essential cell components resultant of decrease in levels ofkey chemical agents or substances involved in cellular regulation andproduction. These agents will typically diminish as a result ofreduction in efficiency over time of glands and organs in the humanbody. Reductions in such key chemical agents are believed to causedamage to the RNA and DNA in each cell nucleus which thereby reduces theability of the cell to reproduce itself which ultimately brings on theaging process which yet further accelerates the decrease in body'sproduction of the key agents. Therefore, the essential problem inanti-aging management is that of maintaining appropriate levels of keymetabolic agents so that the genetic material within each cell will notbecome damaged or otherwise lose efficiency.

Therefore, it is desirable to have improved dietary supplementcompositions that provide nutrients and substances to effectivelysupport optimal cellular functions for the purpose of anti-agingmanagement at both the cellular and organ levels.

SUMMARY

A dietary supplement system includes a first dietary supplementcomposition for oral administration by an individual in the morning,said first composition, comprising: (a) a telomere maintenance complexcomprising: Purslane extract (aerial parts), 4-6 mg; Turmeric rhizomeextract (95% curcuminoids), 20-30 mg; Quercetin dehydrate, 12-18 mg;Cayenne pepper fruit, 8-12 mg; Vanadium (as vanadyl sulfate), 20-30 meg;Fenugreek seed, 20-30 mg; Astragalus root extract, 8-12 mg; Omega fattyacid complex, 160-240 mg, including linoleic acid (10.6%),alpha-linolenic acid (1.3%), oleic acid (1.6%), borage seed oil (10%gamma-linolenic acid), evening primrose oil (4.8% GLA), fish body oil(4.5% eicosapentaenoic acid, 3.0% docosahexaenoic acid); (b) a calorierestriction mimetics and gene expression complex comprising:Trans-resveratrol (from Polygonum cuspidatum root extract), 1.6-2.4 mgPterostilbene (99%), 1.6-2.4 mg; Fisetin 50% (Buxus microphlla Sieb(stem and leaf)), 1.6-2.4 mg; Alpha lipoic acid, 8-12 mg; Coenzyme Q-10,4-6 mg; Betaine HCl, 3.2-4.8 mg; Sulfur (from methylsulfonylmethane),1-1.5 mg; L-Carnitine tartrate, 8-12 mg; L-Carnitine HCl, 4-6 mg; and(c) a free radical scavenger complex, comprising: Green tea leaf extract(40% catechin and polyphenols), 40-60 mg; Anthocyanins (from bilberryfruit and grape skin extracts), 4-6 mg.

DETAILED DESCRIPTION

In one embodiment, the present invention provides a dietary supplementsystem for supporting multifunctional anti-aging management. In oneembodiment, the nutritional supplement system comprises two dietarysupplement compositions, each for oral administration by an individualat a specific time of a day.

In one embodiment, each of the two dietary supplement compositionscomprises multiple sub-functional groups of components, includingtelomere maintenance complex, calorie restriction mimetics and geneexpression complex, free radical scavenger complex, DNA repair complex,stem cell maintenance complex, and cell regulation complex. Furthermore,the dietary supplement compositions also comprise multiple vitamins andminerals. One of the two supplement compositions is designated for oraladministration in the morning, and hence is referred to as AM dietarysupplement composition or AM composition hereinafter, and the othersupplement composition is designated for oral administration in theevening, and hence is referred to as PM dietary supplement compositionor PM composition hereinafter.

Unless defined otherwise, all technical and scientific terms used hereinhave the same meaning as commonly understood by one having ordinaryskills in the art to which the invention belongs. It should also beunderstood that various individual components used herein may have morethan one type of properties.

In the dietary supplement compositions, telomere maintenance complexcomprises a group of components that individually and/or jointly supportmaintaining telomere of the chromosome. The telomere maintenance complexincludes, but not limited to, purslane extract (aerial parts), turmericrhizome extract containing curcuminoids, quercetin dehydrate, cayennepepper fruit, vanadium, fenugreek seed, astragalus root extract,valerian root, omega fatty acid complex including linoleic acid,alpha-linolenic acid, and oleic acid, borage seed oil, evening primroseoil and fish body oil.

The calorie restriction mimetics and gene expression complex comprises agroup of components that individually and/or jointly support calorierestriction mimetics and gene expression. The calorie restrictionmimetics and gene expression complex includes, but not limited to,trans-resveratrol, such as from extract of polygonum cuspidatum root orgrape skin, pterostilbene, fisetin, alpha lipoic acid, coenzyme Q-10,betaine HCl, sulfur, such as from methylsulfonylmethane, L-carnitinetartrate, L-carnitine HCl, acetyl-L-carnitine, and avocado extract.

The free radical scavenger complex comprises a group of components thatindividually and/or jointly function as antioxidant and reduce freeradicals. The free radical scavenger complex includes, but not limitedto, green tea leaf extract containing catechin and polyphenols,anthocyanins such as from bilberry fruit and grape skin extracts, ginkgobiloba leaf extract containing ginkgo flavonglycosides and sesquiterpenelactones, cruciferous vegetable concentrate (broccoli, kale, radish)containing glucosinolates, grape skin extract containing totalphenolics, tomato lycopene extract containing lycopene, rosemary extract(aerial parts), pycnogenol (pine bark extract), lutein such as frommarigold flower extract, and green barley grass (aerial parts).

The DNA repair complex comprises a group of components that individuallyand/or jointly support DNA repairing in both nuclei and mitochondria.The DNA repair complex includes, not limited to, water extract ofUncaria tomentosa containing carboxy alkyl esters, N-acetyl-cysteine,inositol hexaphosphate, and melatonin.

The stem cell maintenance complex comprises a group of components thatindividually and/or jointly support optimal maintenance of stem cellsand gene expression. The stem cell maintenance complex includes, but notlimited to, chlorella algae, spirulina algae, klamath blue-green algae,fuxoxanthin seaweed (whole plant), nori seaweed extract or brown seaweedextract.

The cell regulation complex comprises a group of components thatindividually and/or jointly support optimal cell regulation. The cellregulation complex includes, but not limited to, gotu kola leaf,phosphatidyl choline such as from soy lecithin, DMAE bitartrate,cordyceps sinensis mushroom extract containing cordyceptic acid, royaljelly 3× containing 10-HDA, l-glutamine, taurine, L-phenylalanine,tyrosine, inositol, L-arginine, L-ornithine, guarana seed extract,probiotic blend (lactobacillus acidophilus, lactobacillus plantarum,bifidobacterium bifidum and lactobacillus casei), amylase, neutralprotease, cellulase, lactase, and lipase.

Multiple vitamins in the dietary supplement compositions include, butnot limited to, vitamin A, vitamin C, vitamin D, vitamin E, vitamin K,thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, biotin,and pantothenic acid.

The minerals in the dietary supplement compositions include, but notlimited to iodine, calcium, zinc, selenium, copper, manganese, chromium,and molybdenum. Optionally, the minerals may further includetransitional metal trace elements such as iridium, rhodium, ruthenium,and/or other transitional metal trace elements.

In addition to the active components described above, each compositionmay further include pharmaceutically acceptable medium. Pharmaceuticallyacceptable medium is known to those of ordinary skilled in the art. Inone exemplary embodiment, the medium includes microcrystallinecellulose, croscarmellose sodium, stearic acid, calcium silicate,magnesium stearate, silica and film coat ingredients such ashypromellose, hydroxypropyl cellulose, and polyethylene glycol. Thedietary supplement compositions can be made into various forms suitablefor oral administration, for example powder, granules, capsules,tablets, or liquid.

In the AM and PM dietary supplement compositions, each sub-functionalgroup may have some differences in the components described above, andthe amount or concentration of individual components may be different,since the effects and needs between the two compositions provided atdifferent times of a day may be different.

In one exemplary embodiment, the AM and PM dietary supplementcompositions and the preferred amount of individual components areprovided below in Table 1 and Table 2, respectively. It is noted thatthe amount of individual components is defined as the amount in onedosage or the amount of per serving, which can be contained in one ormore capsules or tablets. For example, 20 to 30 mg of taurine in onedosage can be provided in one or two capsules. The size and number ofcapsules may depend on the manufacturability, which may further dependon the properties of the components and the pharmaceutically acceptablemedium used therein.

TABLE 1 AM Dietary Supplement Composition Amount Per Components ServingTelomere Maintenance Complex Purslane extract (aerial parts) 4-6 mgTurmeric rhizome extract (95% curcuminoids) 20-30 mg Quercetin dihydrate12-18 mg Cayenne pepper fruit 8-12 mg Vanadium (as vanadyl sulfate)20-30 mcg Fenugreek seed 20-30 mg Astragalus root extract 8-12 mg Omegafatty acid complex including linoleic acid (10.6%), alpha- 160-240 mglinolenic acid (1.3%), oleic acid (1.6%)), borage seed oil (10%gamma-linolenic acid), evening primrose oil (4.8% GLA), fish body oil(4.5% eicosapentaenoic acid, 3.0% docosahexaenoic acid) CalorieRestriction Mimetics and Gene Expression Complex Trans-resveratrol (fromPolygonum cuspidatum root extract) 1.6-2.4 mg Pterostilbene (99%)1.6-2.4 mg Fisetin 50% (Buxus microphlla Sieb (stem and leaf)) 1.6-2.4mg Alpha lipoic acid 8-12 mg Coenzyme Q-10 4-6 mg Betaine HCl 3.2-4.8 mgSulfur (from methylsulfonylmethane) 1-1.5 mg L-Carnitine tartrate 8-12mg L-Carnitine HCl 4-6 mg Free Radical Scavenger Complex Green tea leafextract (40% catechin and polyphenols) 40-60 mg Anthocyanins (frombilberry fruit and grape skin extracts) 4-6 mg Ginkgo biloba leafextract (24% ginkgo flavonglycosides, 6% 40-60 mg sesquiterpenelactones) Green barley grass (aerial parts) 20-30 mg DNA Repair Complexwater extract of uncaria tomentosa (containing carboxy alkyl esters)100-150 mg N-acetyl-cysteine 10-15 mg Inositol hexaphosphate 1.6-2.4 mgStem Cell Maintenance Complex Chlorella algae 20-30 mg Spirulina algae40-60 mg Klamath blue-green algae 60-90 mg Fuxoxanthin seaweed (wholeplant) 20-30 mg Nori seaweed extract 1.6-2.4 mg Cell Regulation ComplexGotu kola leaf 8-12 mg Phosphatidyl choline (from soy lecithin) 20-30 mgDMAE bitartrate 20-30 mg Cordyceps sinensis mushroom extract (1%cordyceptic acid) 10-15 mg Royal jelly 3X (5% 10-HDA) 8-12 mgL-Glutamine 40-60 mg Taurine 20-30 mg L-Phenylalanine 20-30 mgL-Tyrosine 20-30 mg Guarana seed extract (20% caffeine) 32-48 mg Amylase480-720 units Neutral protease 120-180 units Cellulase 4-6 units Lactase80-120 units Lipase 2.6-3.9 units Vitamins Vitamin A (as retinylpalmitate and 85% as beta-carotene) 1,440-2,160 IU Vitamin C (asascorbyl palmitate and ascorbic acid) 80-120 mg Vitamin D (ascholecalciferol) 32-48 IU Vitamin E (as d-alpha tocopheryl succinate andfrom mixed natural 40-60 IU tocopherols) Vitamin K (as phytonadione)60-90 mcg Thiamin (as thiamin HCl) 4-6 mg Riboflavin (as riboflavin andriboflavin-5-phosphate) 3.2-4.8 mg Niacin (as niacinamide and niacin)56-84 mg Vitamin B₆ (as pyridoxine HCl and pyridoxal 5-phosphate)9.6-14.4 mg Folate (as folic acid) 40-60 mcg Vitamin B₁₂ (ascyanocobalamin) 64-96 mcg Biotin 40-60 mcg Pantothenic acid (asD-calcium pantothenate) 9.6-14.4 mg Minerals Iodine (as potassium iodideand from kelp) 24-36 mcg Calcium (as calcium carbonate and citrate)240-360 mg Zinc (as zinc glycinate) 1.6-2.4 mg Selenium (asselenomethionine) 24-36 mcg Copper (as copper lysinate) 0.16-0.24 mgManganese (as manganese gluconate) 0.16-0.24 mg Chromium (as chromiumpolynicotinate) 40-60 mcg Molybdenum (as sodium molybdate) 6.4-9.6 mgTransitional metal trace elements including iridium, rhodium, 10-90 μgruthenium

TABLE 2 PM Dietary Supplement Composition Amount Per Component ServingTelomere Maintenance Complex Purslane extract (aerial parts) 4-6 mgTurmeric rhizome extract (95% curcuminoids) 20-30 mg Quercetin dihydrate12-18 mg Cayenne pepper fruit 8-12 mg Vanadium (as vanadyl sulfate)16-24 mcg Fenugreek seed 16-24 mg Valerian root 24-36 mg Omega fattyacid complex including linoleic acid (10.6%), alpha- 160-240 mglinolenic acid (1.3%), oleic acid (1.6%), borage seed oil (10%gamma-linolenic acid), evening primrose oil (4.8% GLA), fish body oil(4.5% eicosapentaenoic acid, 3.0% docosahexaenoic acid) CalorieRestriction Mimetics and Gene Expression Complex Trans-resveratol (asPolygonum cuspidatum root extract or grape 1.6-2.4 mg skin extract)Pterostilbene 1.6-2.4 mg Fisetin 50% (Buxus microphlla Sieb (stem andleaf)) 1.6-2.4 mg Alpha-lipoic acid 8-12 mg Coenzyme Q₁₀ 2.8-4.2 mgBetaine (as betaine-HCl) 2-3 mg Sulfur (from methylsulfonylmethane)0.8-1.2 mg L-Carnitine tartrate 8-12 mg Acetyl-L-carnitine 4-6 mg FreeRadical Scavenger Complex Cruciferous vegetable concentrate (broccoli,kale, radish) (2% 32-48 mg glucosinolates) Grape skin extract (37% totalphenolics) 16-24 mg Tomato lycopene extract (20% lycopene) 1.6-2.4 mgRosemary 4:1 extract (aerial parts) 2.6-3.9 mg Pycnogenol (pine barkextract) 1.32-1.98 mg Lutein (from marigold flower extract) 0.64-0.96 mgGreen barley grass 8-12 mg DNA Repair Complex Water extract of uncariatomentosa (containing carboxy alkyl 100-150 mg esters) Inositolhexaphosphate 1.6-2.4 mg N-Acetyl cysteine 6.4-9.6 mg Melatonin 0.4-0.6mg Stem Cell Maintenance Complex Chlorella algae 20-30 mg Spirulinaalgae 12-18 mg Klamath blue green algae 36-54 mg Fucoxanthin seaweed(whole plant) 20-30 mg Brown seaweed extract 4-6 mg Cell RegulationComplex Phosphatidylcholine (from soy lecithin) 16-24 mg Cordycepssinensis mushroom extract (1% cordycepic acid) 6.6-9.9 mg Royal jelly 3x(5% 10-HDA) 7.2-10.8 mg Inositol 40-60 mg L-Glutamine 200-300 mgL-Arginine (as L-arginine HCl) 128-192 mg L-Ornithine (as L-ornithineHCl) 96-144 mg Taurine 12.8-19.2 mg L-Tyrosine 16-24 mg Probiotic blendincluding Lactobacillus acidophilus, Lactobacillus 40-60 million CFUplantarum, Bifidobacterium bifidum and Lactobacillus casei Amylase320-480 units Neutral protease 80-120 units Lactase 52-78 units Lipase12.8-19.2 units Vitamins Vitamin A (as retinyl palmitate and 85% fromnatural mixed 1,120-1,680 IU carotenoids) Vitamin C (as ascorbic acidand ascorbyl palmitate) 160-240 mg Vitamin D (as cholecalciferol) 24-36IU Vitamin E (as d-alpha-tocopheryl succinate and from mixed natural32-48 IU tocopherols) Vitamin K (as phytonadione) 60-90 mcg Thiamin (asthiamin HCl) 2-3 mg Riboflavin (as riboflavin andriboflavin-5-phosphate) 4-6 mg Niacin (as niacinamide and niacin) 56-84mg Vitamin B₆ (as pyridoxine HCl and pyridoxal-5-phosphate) 6-9 mgFolate (as folic acid) 64-96 mcg Vitamin B₁₂ (as cyanocobalamin) 96-144mcg Biotin 32-48 mcg Pantothenic acid (as D-calcium pantothenate) 16-24mg Minerals Iodine (as potassium iodide and from kelp) 9.6-14.4 mcgMagnesium (as magnesium oxide and glycinate) 106-159 mg Zinc (as zincglycinate) 1.2-1.8 mg Selenium (as selenomethionine) 19.2-28.8 mcgCopper (as copper lysinate) 0.08-0.12 mg Manganese (as manganesegluconate) 0.08-0.12 mg Chromium (as chromium polynicotinate) 32-48 mcgMolybdenum (as sodium molybdate) 6.4-9.6 mcg Transitional metal traceelements including iridium, rhodium, 10-90 μg ruthenium

Preferably, the AM dietary supplement composition is orally administeredin the morning, and the PM dietary supplement composition is orallyadministered in the evening, for example at the bed time. Preferably,the dietary supplement compositions are administered daily as dietary ornutritional supplements. The compositions can be taken with or withoutfood.

The unique combination of the above described telomere maintenancecomplex, calorie restriction mimetics and gene expression complex, freeradical scavenger complex, DNA repair complex, stem cell maintenancecomplex, and cell regulation complex provides synergetic effects foroptimal cellular function. The synergetic effects provide desiredcalorie restriction mimetics, reduce age related deteriorations intelomere maintenance, stem cell function, cell regulation and geneexpression, reduce free radicals at cellular level, and enhance DNArepair in both nuclei and mitochondria. Moreover, the supplementcompositions, through various components and their combination, furtherhave anti-inflammation and anti-oxidation properties, and desiredfunctions in regulating glycation and methylation. Therefore, thedietary supplement compositions provide a multifunctional and effectiveanti-aging management system.

The following example further describes and demonstrates embodimentswithin the scope of the present invention. The examples are given solelyfor the purpose of illustration and are not to be construed aslimitations of the present invention, as many variations thereof arepossible without departing from the spirit and scope of the invention.

EXAMPLE 1

An AM dietary supplement composition shown in Table 3 below wasprepared, with the processes known in the art. The amount per servingdescribed was provided in two capsules.

TABLE 3 Example AM Dietary Supplement Composition Amount Per ComponentServing Telomere Maintenance Complex Purslane extract (aerial parts) 5mg Turmeric rhizome extract (95% curcuminoids) 25 mg Quercetin dihydrate15 mg Cayenne pepper fruit 10 mg Vanadium (as vanadyl sulfate) 25 mcgFenugreek seed 25 mg Astragalus root extract 10 mg Omega fatty acidcomplex including linoleic acid (10.6%), 200 mg alpha-linolenic acid(1.3%), oleic acid (1.6%), borage seed oil (10% gamma-linolenic acid),evening primrose oil (4.8% GLA), fish body oil (4.5% eicosapentaenoicacid, 3.0% docosahexaenoic acid) Calorie Restriction Mimetics and GeneExpression Complex Trans-resveratrol (from Polygonum cuspidatum rootextract) 2 mg Pterostilbene (99%) 2 mg Fisetin 50% (Buxus microphllaSieb (stem and leaf)) 2 mg Alpha lipoic acid 10 mg Coenzyme Q-10 5 mgBetaine HCl 4 mg Sulfur (from methylsulfonylmethane) 1.25 mg L-Carnitinetartrate 10 mg L-Carnitine HCL 5 mg Free Radical Scavenger Complex Greentea leaf extract (40% catechin and polyphenols) 50 mg Anthocyanins (frombilberry fruit and grape skin extracts) 5 mg Ginkgo biloba leaf extract(24% ginkgo flavonglycosides, 50 mg 6% sesquiterpene lactones) Greenbarley grass (aerial parts) 25 mg DNA Repair Complex Water extract ofuncaria tomentosa (containing carboxy 125 mg alkyl Vesters)N-acetyl-cysteine 12.5 mg Inositol hexaphosphate 2 mg Stem CellMaintenance Complex Chlorella algae 25 mg Spirulina algae 50 mg Klamathblue-green algae 75 mg Fuxoxanthin seaweed (whole plant) 25 mg Noriseaweed extract 2 mg Cell Regulation Complex Gotu kola leaf 10 mgPhosphatidyl choline (from soy lecithin) 25 mg DMAE bitartrate 25 mgCordyceps sinensis mushroom extract (1% cordyceptic 12.5 mg acid) Royaljelly 3X (5% 10-HDA) 10 mg L-Glutamine 50 mg Taurine 25 mgL-Phenylalanine 25 mg L-Tyrosine 25 mg Guarana seed extract (20%caffeine) 40 mg Amylase 600 units Neutral protease 150 units Cellulase 5units Lactase 100 units Lipase 25 units Vitamins Vitamin A (as retinylpalmitate and 85% as beta-carotene) 1,800 IU Vitamin C (as ascorbylpalmitate and ascorbic acid) 100 mg Vitamin D (as cholecalciferol) 40 IUVitamin E (as d-alpha tocopheryl succinate and from mixed 50 IU naturaltocopherols) Vitamin K (as phytonadione) 75 mcg Thiamin (as thiamin HCl)5 mg Riboflavin (as riboflavin and riboflavin-5-phosphate) 4 mg Niacin(as niacinamide and niacin) 70 mg Vitamin B₆ (as pyridoxine HCl andpyridoxal 5-phosphate) 12 mg Folate (as folic acid) 50 mcg Vitamin B₁₂(as cyanocobalamin) 80 mcg Biotin 50 mcg Pantothenic acid (as D-calciumpantothenate) 12 mg Minerals Iodine (as potassium iodide and from kelp)30 mcg Calcium (as calcium carbonate and citrate) 300 mg Zinc (as zincglycinate) 2 mg Selenium (as selenomethionine) 30 mcg Copper (as copperlysinate) 0.2 mg Manganese (as manganese gluconate) 0.2 mg Chromium (aschromium polynicotinate) 50 mcg Molybdenum (as sodium molybdate) 8 mgOther ingredients: Microcrystalline cellulose, croscarmellose sodium,stearic acid, calcium silicate, magnesium stearate, silica and film coatingredients (hypromellose, hydroxypropyl cellulose, and polyethyleneglycol).

EXAMPLE 2

A PM dietary supplement composition shown in Table 4 below was prepared,with the processes known in the art. The amount per serving describedwas provided in two capsules.

TABLE 4 Example PM Dietary Supplement Composition Components Amount PerServing Telomere Maintenance Complex Purslane extract (aerial parts) 5mg Turmeric rhizome extract (95% curcuminoids) 25 mg Quercetin dihydrate15 mg Cayenne pepper fruit 10 mg Vanadium (as vanadyl sulfate) 20 mcgFenugreek seed 20 mg Valerian root 30 mg Omega fatty acid complexincluding linoleic acid 200 mg (10.6%), alpha-linolenic acid (1.3%),oleic acid (1.6%), borage seed oil (10% gamma-linolenic acid), eveningprimrose oil (4.8% GLA), fish body oil (4.5% eicosapentaenoic acid, 3.0%docosahexaenoic acid) Calorie Restriction Mimetics and Gene ExpressionComplex Resveratol (as Polygonum cuspidatum root extract) 2 mgPterostilbene 2 mg Fisetin 50% (Buxus microphlla Sieb (stem and leaf)) 2mg Alpha-lipoic acid 10 mg Coenzyme Q₁₀ 3.5 mg Betaine (as betaine-HCl)2.5 mg Sulfur (from methylsulfonylmethane) 1 mg L-Carnitine tartrate 10mg Acetyl-L-carnitine 5 mg Free Radical Scavenger Complex Cruciferousvegetable concentrate (broccoli, kale, 40 mg radish) (2% glucosinolates)Grape skin extract (37% total phenolics) 20 mg Tomato lycopene extract(20% lycopene) 2 mg Rosemary 4:1 extract (aerial parts) 3.25 mgPycnogenol (pine bark extract) 1.65 mg Lutein (from marigold flowerextract) 0.8 mg Green barley grass 10 mg DNA Repair Complex Waterextract of uncaria tomentosa (containing 125 mg carboxy alkyl esters)Inositol hexaphosphate 2 mg N-acetyl cysteine 8 mg Melatonin 0.5 mg StemCell Maintenance Complex Chlorella algae 25 mg Spirulina algae 15 mgKlamath blue green algae 45 mg Fucoxanthin seaweed (whole plant) 25 mgBrown seaweed extract 5 mg Cell Regulation Complex Phosphatidylcholine(from soy lecithin) 20 mg Cordyceps sinensis mushroom extract 8.25 mg(1% cordycepic acid) Royal jelly 3x (5% 10-HDA) 9 mg Inositol 50 mgL-Glutamine 250 mg L-Arginine (as L-arginine HCl) 160 mg L-Ornithine (asL-ornithine HCl) 120 mg Taurine 16 mg L-Tyrosine 20 mg Probiotic blendincluding Lactobacillus acidophilus, 50 million CFU Lactobacillusplantarum, Bifidobacterium bifidum and Lactobacillus casei Amylase 400units Neutral protease 100 units Lactase 65 units Lipase 16 unitsVitamins Vitamin A (as retinyl palmitate and 85% from 1,400 IU naturalmixed carotenoids) Vitamin C (as ascorbic acid and ascorbyl palmitate)200 mg Vitamin D (as cholecalciferol) 30 IU Vitamin E (asd-alpha-tocopheryl succinate and 40 IU from mixed natural tocopherols)Vitamin K (as phytonadione) 75 mcg Thiamin (as thiamin HCl) 2.5 mgRiboflavin 5 mg (as riboflavin and riboflavin-5-phosphate) Niacin (asniacinamide and niacin) 70 mg Vitamin B₆ 7.5 mg (as pyridoxine HCl andpyridoxal-5-phosphate) Folate (as folic acid) 80 mcg Vitamin B₁₂ (ascyanocobalamin) 120 mcg Biotin 40 mcg Pantothenic acid (as D-calciumpantothenate) 20 mg Minerals Iodine (as potassium iodide and from kelp)12 mcg Magnesium (as magnesium oxide and glycinate) 132.5 mg Zinc (aszinc glycinate) 1.5 mg Selenium (as selenomethionine) 24 mcg Copper (ascopper lysinate) 0.1 mg Manganese (as manganese gluconate) 0.1 mgChromium (as chromium polynicotinate) 40 mcg Molybdenum (as sodiummolybdate) 8 mcg Other ingredients: Microcrystalline cellulose,croscarmellose sodium, stearic acid, calcium silicate, magnesiumstearate, silica and film coat ingredients (hypromellose, hydroxypropylcellulose, and polyethylene glycol).

All publications, patent applications, patents, and other referencesmentioned herein are incorporated by reference in their entirety.

While the invention has been disclosed in connection with certainpreferred embodiments, this should not be taken as a limitation to allof the provided details.

Modifications and variations of the described embodiments may be madewithout departing from the spirit and scope of the invention, and otherembodiments should be understood to be encompassed in the presentdisclosure as would be understood by those of ordinary skill in the art.

What is claimed is:
 1. A dietary supplement system comprising: (i) afirst dietary supplement composition for oral administration to anindividual, said first composition comprising: (a) a telomeremaintenance complex comprising: Purslane; Turmeric rhizome extract;Quercetin dehydrate; Cayenne pepper fruit; Vanadium (as vanadylsulfate); Fenugreek seed; Astragalus root extract; and an Omega fattyacid complex, including linoleic acid, alpha-linolenic acid, oleic acid,borage seed oil, evening primrose oil, eicosapentaenoic acid anddocosahexaenoic acid; (b) a calorie restriction mimetics and geneexpression complex comprising: Trans-resveratrol; Pterostilbene (99%);Fisetin 50%; Alpha lipoic acid; Coenzyme Q-10; Betaine HCl; Sulfur; andL-Carnitine; (c) a free radical scavenger complex comprising: Green tealeaf extract; Anthocyanins; Ginkgo biloba leaf extract; and Green barleygrass; (d) a DNA repair complex comprising: a Water extract of Uncariatomentosa; (e) a stem cell maintenance complex comprising: Chlorellaalgae; Spirulina algae; Klamath blue-green algae; fucoxanthin-containingseaweed (whole plant); and Nori seaweed extractract; (f) a cellregulation complex comprising: Gotu kola leaf; Phosphatidyl choline;dimethylaminoethanol (DMAE); Cordyceps sinensis mushroom extract; Royaljelly 3× (5% 10-hydroxy-2-decenoic acid); L-Glutamine; Taurine;L-Phenylalanine; L-Tyrosine; Guarana seed extract; Amylase; Neutralprotease; Cellulase; Lactase; and Lipase; (g) Vitamin K; and (h) a groupof minerals comprising: Iodine; Calcium; Zinc; Selenium; Copper;Manganese; Chromium; and Molybdenum; and (ii) a second dietarysupplement composition for oral administration to the individual, saidsecond composition comprising: (a) a telomere maintenance complexcomprising: Purslane extract; Turmeric rhizome extract; Quercetindehydrate; Cayenne pepper fruit; Vanadium; Fenugreek seed; Valerian rootextract; and an Omega fatty acid complex, including linoleic acid,alpha-linolenic acid, oleic acid, borage seed oil, evening primrose oil,eicosapentaenoic acid and docosahexaenoic acid; (b) a calorierestriction mimetics and gene expression complex comprising:Resveratrol; Pterostilbene; Fisetin 50%; Alpha-lipoic acid; CoenzymeQ10; Betaine; Sulfur; L-Carnitine tartrate; and Acetyl-L-Carnitine; (c)a free radical scavenger complex comprising: Cruciferous vegetableconcentrate; Grape skin extract; Tomato lycopene extract; Rosemaryextract; Pycnogenol; Lutein; and Green barley grass; (d) a DNA repaircomplex comprising: a Water extract of Uncaria tomentosa; Inositolhexaphosphate; N-acetyl cysteine; and Melatonin; (e) a stem cellmaintenance complex comprising: Chlorella algae; Spirulina algae;Klamath blue green algae; Fucoxanthin-containing seaweed; and Brownseaweed; (f) a cell regulation complex comprising: Phosphatidyl choline;Cordyceps sinensis mushroom extract; Royal jelly 3×; Inositol;L-Glutamine; L-Arginine; L-Ornithine; Taurine; and L-Tyrosine; (g)Vitamin K; and (h) a group of minerals comprising: Iodine; Magnesium;Zinc; Selenium; Copper; Manganese; Chromium; and Molybdenum.
 2. Thesupplement system of claim 1 further comprising a pharmaceuticallyacceptable medium.
 3. The supplement system of claim 1 wherein thesupplement is formulated for oral administration.
 4. The supplementsystem of claim 3 wherein formulations for oral administration arepowders, granules, capsules, tablets or liquids.
 5. The supplementcomposition of claim 1 is for administration to subject in need of ananti-aging management system.